Should pituitary suppressive medications be stopped prior to radiosurgery for patients with a functioning pituitary adenoma?

Topics: Radiation Oncology • Neuro-Oncology • Stereotactic Radiosurgery

If so, how long should the medication be stopped prior to SRS?

Answer from: Radiation Oncologist at Academic Institution

The first reported significantly lower hormone normalization rate was in acromegaly patients who were receiving antisecretory medications at the time of radiosurgery. Subsequently, similar finding was reported in prolactinoma patients. The suggested rationale is antisecretory medications alter ...

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Radiation Oncologist at East Alabama Medical Center
How soon after RT is complete would you re-start s...

Answer from: Radiation Oncologist at Community Practice

The strongest "evidence" for holding anti-secretory medication is probably for GH secreting tumors / acromegaly, though those studies are as previously mentioned retrospective. Furthermore, I feel like most (all?) of the endpoints in those retrospective studies were regarding IGH-1 normalization. T...

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