The jury is really still out on the issue of whether or not to add thoracic radiation therapy to prophylactic cranial irradiation (PCI) in patients with extensive-stage small cell lung cancer. The published data cited above, Slotman et al. in Lancet last Fall 2014, indicate that there may be an ove...

I agree with @Jeffrey D. Bradley. A few pertinent points: The CREST /Slotman trial was to show a benefit at one year, and that did not occur. Few survive to two years in the ED group. Opposite of what we usually expect, those that achieved a CR to chemotherapy seemed to benefit least, and those may ...