Should we be aiming for normalization of both late-night salivary cortisol and 24hr urinary free cortisol levels when monitoring response to Cushing's disease treatment?
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Should normalization of both late-night salivary cortisol and 24-hour urinary free cortisol levels be the goal when monitoring response to Cushing's disease treatment?
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2 Answers
Mednet MemberInvited Expert
Endocrinology · Johns Hopkins Endocrinology and Pituitary Center
Answered on
I usually follow UFC, but there is some data that in patients with Cushing disease treated with pasireotide there was a greater improvements in systolic/diastolic blood pressure and weight in patients with both normal late night salivary cortisol and UFC compared with only normal UFC (see: Newell-Pr...
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Mednet MemberInvited Expert
Endocrinology · Kaiser Permanente Oakland Medical Center Endocrinology
Answered on
Ideally, yes, both should be normal. 24 hour UFC may increase but still be within the normal range so normal salivary cortisol provides additional reassurance.
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