Topics:
Breast Cancer • Medical Oncology • Journal Club ft. NEJM publications • BRCA+ • Breast Cancer, Non-metastatic • ASCO 2021
Should we start performing universal germline mutation testing for all newly diagnosed breast cancer?
Given OlympiA trial with olaparib benefit for gBRCA+ patients?
What are barriers that you foresee? In your practice who performs mutation testing and who counsels patients? Is this performed as part of tumor board or addressed by med onc during initial visits?
Answer from: Medical Oncologist at Academic Institution
The new NCCN guidelines indicate testing all metastatic breast cancer patients for PARP inhibitor consideration and testing eligible patients (per OlympiA study) for adjuvant Olaparib consideration.There is no ideal way to provide genetic counseling for all eligible breast cancer patients that prese...
Answer from: Medical Oncologist at Academic Institution
One has to bear in mind that BRCA mutations are extremely uncommon in women who are over the age of 60 and do not meet NCCN criteria. Up to 40% of all women with breast cancer fall into this category. Also, not all breast cancer patients would have met the eligibility criteria for OlympiA. So while ...
Answer from: Medical Oncologist at Academic Institution
While universal germline testing for all newly diagnosed breast cancer may not be indicated, I think the majority of patients with a diagnosis of breast cancer should be offered testing given implications on treatment decision-making and future preventive care. I offer genetic testing as per NCCN gu...
Answer from: Medical Oncologist at Community Practice
Should we start performing universal germline mutation testing for all newly diagnosed breast cancer? Short answer: No, not yet. The argument that expanded multi-gene screening (80 genes or more) for all breast cancer patients should be balanced against the genetic testing for breast cancer pat...
Interesting perspective. Would this be cost effect...
In an ideal world, universal germline testing woul...
In Israel, it is offered to all newly diagnosed pa...
I think that the only group of patients who will n...
In Puerto Rico, it is my hypothesis that we have a...
It is true that different types of testing should ...