Under what circumstances do you consider valacyclovir for the management of VZV disease of the CNS?

Under what circumstances do you consider transitioning from IV acyclovir to high-dose oral valacyclovir for patients with VZV disease of the CNS?

• I transition to high-dose oral valacyclovir only after the patient shows improvement with IV acyclovir
• I consider transitioning to high-dose oral valacyclovir after 1-2 weeks of IV acyclovir, especially in outpatient settings, regardless of the patient's improvement
• I do not transition to high-dose oral valacyclovir and instead continue IV acyclovir throughout the treatment duration
• Other