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Under what circumstances would you consider low-dose radiation therapy for osteoarthritis in an older adult patient?

This question is part of our ASTRO 2026 collaboration, inspired by the Clinical Trials Session Presentation "Randomized Trial of Low-Dose Radiotherapy for Knee Osteoarthritis: Patient-Reported, Structural and Long-Term Clinical Endpoints" by Dr. Maria Makarova, MD
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Under what circumstances would you consider low-dose radiation therapy for osteoarthritis in an older adult patient?

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3 Answers
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Rheumatology · Duke University Medical Center
Answered on

Here is a recent expert consensus by Joel Block on the use of low-dose radiation therapy in OA:

Some highlights:

"Placebo-controlled randomized clinical trials have now been reported using LDRT for OA of the knees and of the hands. Taken together, they do not show benefit beyond placebo... While a d...

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Radiation Oncology · LJA
Answered on

Almost any and all circumstances.

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Radiation Oncology · Keck School of Medicine of USC
Answered on

I believe that older adult patients are often the ones who can benefit most from LDRT. These patients often have osteoarthritis in multiple joints and are the same patients suffering from comorbid conditions that limit the use of systemic analgesic medications, including NSAIDs and Acetaminophen. In...

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