Under what circumstances would you perform selective stereotactic radiosurgery to patients with multiple sub-centimeter brain metastases and 1-2 slightly larger brain metastases?

In our practice, select lesion radiosurgery is used in 3 scenarios:

1. Patient has good CNS-penetrating systemic therapy options for treatment of brain metastases that will be starting soon. Lesions chosen then would be larger lesions and lesions in critically located regions of the brain (e.g., brain...