Under what circumstances you would consider treating stage II colon cancer with adjuvant chemotherapy?

This is a very interesting question especially at present time.

We know not every patient with stage II colon cancer will benefit from adjuvant chemotherapy, and the absolute survival benefit is less than 5% for 5FU based adjuvant chemo treatment (but no category 1 evidence). Oxaliplatin-based adjuvant treatment also did not show strong evidence of survival benefit (but there was DFS benefit) (Toumigand C, et al. J. Clin Oncol 2012; 30:3353). So adjuvant treatment for stage II colon cancer patie...