What adjuvant therapy do you give after surgery to patients with gastric CA who undergo 3 cycles of FLOT with no tumor effect on pathology and maintain good PS?
I understand the perioperative trials are not based on tumor regression in cancer cells.
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What adjuvant therapy do you give after surgery to patients with gastric CA who undergo 3 cycles of FLOT with no tumor effect on pathology and maintain good PS?
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3 Answers
Mednet Member
Radiation Oncology · Vanderbilt-Ingram Cancer Center
Answered on
I know I'm not a medical oncologist in a question (and disease site) geared towards med-oncs, but I would caution against such definitive statements about RT (agree with @Dr. First Last on ECF) when subset analyses of the CRITICS trial evaluating the role of TRG (along with other factors, such as no...
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Mednet MemberInvited Expert
Medical Oncology · Memorial Sloan Kettering Cancer Center
Answered on
I’ve answered a similar variant of this question before:
The only thing I would change is that adjuvant chemoradiation is now totally off the table based on a lack of benefit in the ARTIST-2 study, which randomized patients with positive LNs at surgery to ad...
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Mednet Member
Medical Oncology · Tufts University School of Medicine
Answered on
Thank you so much for all your insights and great responses. They did receive 4 cycles per FLOT4 and not 3. Agree with no adjuvant radiation unless margins positive.
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