What adjuvant therapy do you give after surgery to patients with gastric CA who undergo 3 cycles of FLOT with no tumor effect on pathology and maintain good PS?
What adjuvant therapy do you give after surgery to patients with gastric CA who undergo 3 cycles of FLOT with no tumor effect on pathology and maintain good PS?
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I know I'm not a medical oncologist in a question (and disease site) geared towards med-oncs, but I would caution against such definitive statements about RT (agree with @Dr. First Last on ECF) when subset analyses of the CRITICS trial evaluating the role of TRG (along with other factors, such as node positivity and ypT3/T4 disease) have not been presented/published (to my knowledge, happy to be educated).
To extrapolate ARTIST-II (which did not have neoadjuvant chemotherapy) to this scenario doesn't seem to make much sense.
While the future of RT in gastric cancer is most likely in the pre-operative setting (TOPGEAR, CRITICS-II, amongst others), the posed question of poor responders to upfront chemotherapy does not have sufficient data to c...
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I’ve answered a similar variant of this question before:
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Thank you so much for all your insights and great responses. They did receive 4 cycles per FLOT4 and not 3. Agree with no adjuvant radiation unless margins positive.
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