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What adjuvant therapy would you offer for a cisplatin-eligible patient with upper tract urothelial carcinoma and Lynch Syndrome?

Would T or N group change your recommendation?
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In a cisplatin-eligible patient with upper tract urothelial carcinoma and Lynch Syndrome, what adjuvant therapy would you offer?

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1 Answer
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · University of Washington School of Medicine
Answered on

Good question and discussed it with Dr. @Dr. First Last. We have seen data from the POUT phase 3 trial (Birtle et al., PMID 32145825) showing significant DFS benefit with adjuvant Gem/Cis vs observation after radical surgery (due to study closure the trial was not powered to show OS benefit) in pati...

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