What adjuvant treatment would you offer a patient with adenocarcinoma of the mid-esophagus cT2N0M0 who underwent upfront esophagectomy, which showed T2N1 disease with negative margins?

Unfortunately, it's not an uncommon situation for patients to be upstaged following surgery without prior preoperative chemotherapy. This is because imaging modalities and even endoscopic ultrasound have limited sensitivity for detecting lymph node metastases.

A related issue is whether patients with...

Mid and distal esophageal adenocarcinomas are biologically and clinically similar, with comparable metastatic patterns and outcomes and show similar molecular profiling. (Nakauchi et al., PMID 38841851)

For resectable esophageal adenocarcinomas, the NCCN guidelines list FLOT + durvalumab as a periope...