This is a question of high clinical importance but with a lack of good controlled data. First and foremost, a holiday should be viewed as a temporary discontinuation of therapy. Anecdotally, I would say about 30% of my patients need to go back on therapy. There is a lack of data to support clinical ...

If the patient remains at high risk for fracture with a high FRAX index, I would consider an anabolic agent such as Teraparatide or Romosozumab. If the risk of fracture was modest, an anti-resorptive agent such as Denosumab or even a shorter half life bisphosphonate could be utilized. Remember, the ...