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What antibiotic, antifungal and antiviral prophylaxis you give post CAR-T therapy, and what is the duration?

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What anti-infectious prophylaxis do you use for patients receiving CD19 CAR T therapy?

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1 Answer
Mednet Member
Mednet MemberInvited Expert
Hematology · Hospital of the University of Pennsylvania
Answered on

This is a critical issue as more patients are being treated with CAR-T cell therapy.

My approach would be as follows:

  • Antiviral PPx: I usually consider acyclovir PPx for at least 1 year

  • Antifungal PPx: Consider fluconazole PPx for initial neutropenia if it is prolonged beyond a week ---> once the c...

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