What antidepressant medications do you usually use alongside ketamine or esketamine treatment in patients with difficult-to-treat depression?

Hello--ketamine clinic psych here. In our clinic's experience, quite a few ketamine-responders can drop the number of medications or lower the doses of medications once ketamine is part of the treatment plan. We don't see a lot of difference between which medication works best since that is so varia...

Truly, I have not appreciated significant differences among concurrent medications. I believe there have been some theoretical concerns about antidepressants and other psychiatric medications that should not be used along with ketamine, but I don’t believe these concerns panned out in clinical pract...