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What are outpatient strategies to mitigate taxane-induced peripheral neuropathy?

Are there any protocols in place? Aside from telling patients to use ice packs or bags or immerse hands/feet in ice water baths from 15" before to 15" after chemotherapy, are there any other cooling devices on the market that anyone would recommend? Is anyone routinely recommending this for patients at high risk of chemo induced sensory neuropathy due to pre diabetes/diabetes/underlying neuropathy?
3 Answers
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Medical Oncology · Mayo Medical School
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At the present time, there are no established means for preventing taxane-induced neuropathy other than limiting the dose that is given. In patients who are receiving taxane therapy and have developed significant neuropathy, ASCO guidelines suggest that discussion should be had with patients with re...

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Medical Oncology · Yale
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It is interesting that randomized trials have not shown an improvement in neuropathy using cryotherapy. We use docetaxel most commonly in the breast and prostate population. Since instituting cryotherapy approximately two years ago, the incidence of neuropathy and nail changes has dramatically decre...

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Neurology · University of Maryland School of Medicine
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Sensorimotor training (SMT) exercises, or progressive difficulty balance exercises, have shown to be helpful in both reducing symptoms and may potentially delay onset of CIPN.

In patients with neuropathy, SMT has been shown to reduce abnormal sensations, reduce pain scores, improve vibration sensatio...

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