What are some explanations for the persistent renal outcome disparity gaps affecting certain minority groups of patients with pediatric SLE despite improvement in overall renal outcomes?

There are likely some genetic causes, for example, Blazer et al., PMID 33461980 have shown in a Ghanian cohort of patients with SLE that apolipoprotein 1 risk variants are associated with progressive renal failure. However, it is undeniable that in the US, children in minoritized groups are dispropo...

While it wasn’t possible for us to determine this from our data, I think it’s important to keep in mind that treatment paradigms or healthcare practices that benefit a population on average do not necessarily address the root causes of disparities. As an example, if residential neighborhoods are hig...