What are some potential considerations for the management and treatment of a child with a combined locally and distantly recurrent Papillary Tumor of the Pineal Region previously treated with focal radiation and chemotherapy?  

Is there a role for surgery?

Are there any systemic therapy options?

Should salvage CSI be considered and if so how would you handle the prior 54 Gy field, and what should the goal cumulative dose be for the areas of recurrent disease in the brain and spine?

How should radiation and chemotherapy be sequenced?