What are the advantages of oral octreotide acetate over its long acting injectable formulation for treatment of acromegaly?

Oral octreotide has been associated with improved patient-reported QoL measures compared with those reported for injectable lanreotide and octreotide, and a lower incidence of breakthrough symptoms. However, not all patients who are controlled by injections end up maintaining control. Usually, when switching from injections, I start oral octreotide (20 mg bid) the day that the injection would be due, and repeat IGF-1 month later, keeping in mind that injections can have some persisting effect. O...