What are the best labs to trend improvement in HLH?
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Other than a CBC and LFTs, what labs do you monitor during HLH treatment?
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2 Answers
Mednet Member
Pediatric Hematology/Oncology · UCSF Medical Center-Mission Bay
Answered on
Unfortunately, there is not one specific laboratory test to definitively trend responses to HLH directed therapy. In general, our approach is to obtain baseline inflammatory labs including CBC with differential, ferritin, soluble IL2 receptor (sIL2r), triglycerides, coagulation studies (PT/PTT) including fibrinogen, and LFTs. A cytokine panel, CXCL9, and IL18 can also be helpful to obtain at baseline. We follow these serials to evaluate response to therapy. Of these tests, sIL2R is the most sens...
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Mednet Member
Rheumatology · Carilion Clinic
Answered on
Ferritin changes fast with inflammatory markers.
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