What are the indications for PMRT in an ER/PR(+) Her-2(-) patient with a complete pathologic response in the nodes after neoadjuvant chemo, but with residual disease in the breast?

Topics: Breast Cancer • Radiation Oncology

Answer from: Radiation Oncologist at Academic Institution

This is an area where there is still a paucity of information. Hence, all guidelines need to be very tentative. I recommend PMRT for all patients having biopsy-proven axillary node involvement prior to chemotherapy, as I am concerned these are the patients at highest risk of local-regional failure....

Comments

Radiation Oncologist at Washington University in St Louis
I also include patients with cT1-2cN1 or cT3cN0-1 ...

Radiation Oncologist at University of Colorado School of Medicine
Agree with @Abram Recht except for the cT3N0, thou...

Answer from: Radiation Oncologist at Community Practice

Subject to ongoing/completed NSABP B-51. Off trial, will get different answers based on whom you talk to. In our practice, would offer if pre chemo was T3 or N2 disease or residual disease more than 2 cm in breast.

Comments

Radiation Oncologist at Sarasota Memorial Hospital
How does ypTis disease influence decision to offer...

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