What are the indications for use of inclisiran over anti-PCSK9 monoclonal antibody therapies?

Dr. @Dr. First Last has summarized the case for inclisiran in some patients very well. There is a growing sense that it's important to administer the injection as directed, that is, subcutaneously, not intramuscularly.

Inclisiran and the PCSK9 inhibitors have similar indications. Inclisiran, however, does not currently have CV outcomes data and is a bit less effective at lowering LDL on average. I discuss both options with my patients and ultimately rely on their preference but generally recommend evolocumab or al...