What are the main differences between TRYNGOLZA and Redemplo?

TRYNGOLZA (olesarsen) and Redemplo (plozasiran) both work to reduce apoC-III production, a known inhibitor of LPL activity, thus leading to significant triglyceride lowering. Olezarsen is an antisense oligonucleotide, and plozasirin is an siRNA. Both lower triglycerides by 40-60% and both are FDA-ap...