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What are the preferred inotropes/vasopressors agents for cardiogenic shock in situations with and without LVOT obstruction?

Is there literature to support superiority of levophed over dobutamine, or vice versa?
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Which is your agent of choice - patient BP 90/50 (63) mmHg, HR 105 bpm?

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1 Answer
Mednet MemberInvited Expert
Cardiology · Mount Sinai Heart
Answered on

Randomized evidence to support an answer to this question is lacking.

As the question recognizes, "cardiogenic shock" encompasses a diversity of anatomic and hemodynamic substrates of disease. Left ventricular outflow tract obstruction, which may be fixed or dynamic, a baseline feature or acutely acquired, represents one such critical variable in pathology. Although randomized comparisons are sparse, intuition and clinical experience suggest that "one size does not fit all" when it comes to inotropes and pressors.

For patients with a dynamic left ventricular outflow tract obstruction, other things being equal, interventions that tend to predominantly (a) decrease left ventricular afterload, (b) decrease left ventricular preload, and (c) inc...

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