What are your indications for radiotherapy in children with pleomorphic xanthoastrocytoma?

Topics: Radiation Oncology • Pediatric Oncology

Would you manage this histology any differently relative to other low grade gliomas? Is a STR a definite indication for postoperative XRT?

Answer from: Radiation Oncologist at Academic Institution

Pleomorphic Xanthoastrocytoma is unique among other pediatric low grade gliomas in that it there is a high frequency of targetable alterations including BRAF V600E alterations and that there appears to be an increased risk of transformation relative to other pediatric low grade glioma histologies (P...

Comments

Radiation Oncologist at Tunnell Cancer Center
For a young adult with PXA, would STR be an indica...

Radiation Oncologist at St Jude Children's Research Hospital
I wouldn't advise using NCCN guidelines for most p...

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