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What are your preferred IHC stain(s) for desmoplastic melanoma?

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What is your overall favorite melanocytic marker?

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1 Answer
Mednet Member
Dermatology · New York University
Answered on · Updated on

Desmoplastic melanoma (DM) often comprises variably atypical spindle cells in the dermis within a collagenous stroma and surrounding solar elastosis. By histology, DM can mimic benign processes such as scar or neurofibroma, in addition to other malignancies such as sarcomatoid carcinoma, atypical fibroxanthoma (AFX), or malignant peripheral nerve sheath tumor (MPNST). Useful characteristic histologic features (e.g., overlying melanoma in situ, lymphoid aggregates, etc) are often missing in a hig...

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