What are your top takeaways in Radiation Oncology from SABCS 2024?

Wine regions have good years and bad years. This year's vintage from San Antonio was exceptionally fine, with oral presentations of several important, highly anticipated trials. The second and third of the studies I will discuss were also published on the day of the oral presentation.

1. GS2-03: Kunk...

1. The EUROPA trial. This trial presented at SABCS, and published concurrently in Lancet Oncology, is a non-inferiority, phase 3 trial of women age 70 or older with stage I breast cancer (any grade if tumor <1cm, grade 1-2 if tumor 1.1-1.9 cm; ER and PR >=10%, HER2 negative, and Ki67 <=20%) who were r...

1. EUROPA trial was a phase 3 study that enrolled patients who were >= 70 yo with early-stage, luminal A breast cancer to RT vs adjuvant endocrine therapy. The team presented their preplanned interim analysis that met one of their primary endpoint of quality of life at 24 mo with better QOL in the arm...

1. The value of post-mastectomy radiation unclear
2. Postmenopausal patients may be able to forgo radiation if they are ok getting whole breast irradiation