What brachytherapy dose/fractionation should be used for small cell carinoma of the cervix?
I treat a small cell carcinoma of the cervix the same as a squamous cell or adenocarcinoma as far as the RT portion of treatment. I would give 45 Gy pelvic RT (I would treat PA if involved or if there are positive pelvic nodes). I would give SIB to positive nodes to 55 Gy (2.2 Gy/fx) in the pelvis and 57.5 Gy (2.3Gy/fx) out of the pelvis. This is how nodes are boosted in EMBRACE II. Sequential nodal boosts to equivalent EQD2 is also acceptable.
For brachytherapy, I give 7 Gy x 4 fx but 8Gy x 3 fx or 5.5-6Gy x 5 fx are acceptable. The goal is at least 80 Gy EQD2 to the HR CTV and > 85 Gy if possible for IIB or above.
What is different is chemotherapy. Patients with small cell cervical cancer should receive cisplatin and etoposide-based chemoth...
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