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What brain imaging findings do you find reliable to help support a diagnosis of idiopathic intracranial hypertension?

2 Answers
Mednet MemberInvited Expert
Neurology · UPMC
Answered on

In a study by Bidot et al., PMID 26457687, transverse venous sinus stenosis (TVSS) was the most useful sign of IIH because of its high pooled sensitivity (97%) and specificity(93%). Orbital findings, such as optic nerve head protrusion, posterior scleral flattening, optic nerve tortuosity, and distention of the optic nerve sheath were previously found to be more specific for IIH (with pooled specificities of 99%, 98%, 90%, and 89%, respectively) but to be less sensitive (with pooled sensitivitie...

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Mednet MemberInvited Expert
Neurology · University of Iowa
Answered on

To assess the reliability of MRI findings in idiopathic intracranial hypertension (IIH), one must consider the sensitivity and specificity of each marker, and reports of these percentages vary widely. Bilateral transverse venous sinus stenosis (TVSS) is the most sensitive and specific neuroradiologic indicator, with a pooled sensitivity of 97% and a specificity of 93%.

However, MRI signs suggestive of IIH are frequently observed in the general population undergoing brain imaging. A prospective st...

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