What chemotherapeutic regimen would you use to treat locally recurrent TNBC?

Triple Negative Breast Cancers are sensitive to DNA-damaging agents so I would be inclined to use carbo/taxol or cisplatin/gemcitabine regimen. There are several points that I consider important to make"

1. If there an accessible metastatic site to biopsy, then biopsy it. It gives confirmation to th...

Hi Anthony

You are correct, in the absence germ mutation of BRCA gene olaparib will not be effective. Whereas if the tumor has a somatic mutation then the combination of carboplatin and a Parp inhibitor Is likely to be effective. I said this in my answer.

Cheers

Charlie Shapiro