What chemotherapy regimen would you use for a testicular cancer patient in need of BEPx3 but unable to use platinum based chemotherapy regimen due to cochlear implants?
Answer from: Medical Oncologist at Academic Institution
To be succinct, the correct answer is BEP x 3 if he wants the therapy that would achieve optimal cure rate. If disease is limited to retroperitoneal nodes, especially if < 3 cm is the largest node and normal postorchiectomy, serum hCG and AFP, RPLND would then be the preferred option.
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Answer from: Medical Oncologist at Community Practice
On clinical studies and initial phase I-II trials, it has been shown that sodium thiosulfate (STS) has a potential otoprotective effect, with maximum efficacy occurring when STS is administered 4 to 8 hours after cisplatin. Pharmacokinetic data and further analysis showed that 6 hours was a safe tim...