What chemotherapy regimen would you use for a testicular cancer patient in need of BEPx3 but unable to use platinum based chemotherapy regimen due to cochlear implants?

To be succinct, the correct answer is BEP x 3 if he wants the therapy that would achieve optimal cure rate. If disease is limited to retroperitoneal nodes, especially if < 3 cm is the largest node and normal postorchiectomy, serum hCG and AFP, RPLND would then be the preferred option.

On clinical studies and initial phase I-II trials, it has been shown that sodium thiosulfate (STS) has a potential otoprotective effect, with maximum efficacy occurring when STS is administered 4 to 8 hours after cisplatin. Pharmacokinetic data and further analysis showed that 6 hours was a safe time for the delayed administration of sodium thiosulfate in order to avoid tumor protection. Harned et al., PMID 18223229, Erdlenbruch et al., PMID 11599657.

On September 20, 2022, the FDA approved sodiu...