What chemotherapy regimen would you utilize for a metastatic, poorly differentiated carcinoma of the cervix with neuroendocrine features?

If confirmed neuroendocrine and PD-L1 pending, how would you treat?

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For metastatic neuroendocrine carcinoma of the cervix, PD-L1 status unknown, how would you proceed?

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3 Answers

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Gynecologic Oncology · UCSD Moores Cancer Center

Answered on

I would work with pathology to define if this is a true neuroendocrine cervical cancer versus a poorly differentiated cervical carcinoma with neuroendocrine features. This could potentially impact treatment decisions. I treat patients with poorly differentiated metastatic cervical carcinoma with the...

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Gynecologic Oncology · Cooper Medical School of Rowan University

Answered on

In the absence of high quality data for small cell carcinoma of the cervix, I'd use a regimen similar to small cell ca of the lung: carboplatin/etoposide or cisplatin/etoposide.

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Medical Oncology · The Ohio State University Comprehensive Cancer Center

Answered on

To compare with NET tumors, I wonder if anyone checks Ki67% to base decisions on this value?

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