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What do you view as the role for docetaxel+ramucirumab for patients with metastatic NSCLC in light of LUNG-MAP S1800A data?

Would you still use ram/doce in 3rd or later lines after ram/pembro?
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In a patient who has received ram/pembro in 2nd line, would you still use ram/doce after progression?

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3 Answers
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Medical Oncology · Columbia University Medical Center
Answered on

I still think, at this moment, docetaxel/ramucirumab should be considered standard of care (more below). I would not yet transition to pembro/ram for everyone. A broader issue raised by this trial is whether anti-VEGF drugs, or immunotherapy regimens, alter the efficacy of concurrent or subsequent c...

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Mednet MemberInvited Expert
Medical Oncology · Georgetown University
Answered on

If a patient has previously received both platinum-doublet chemotherapy and ICI (either concurrently or sequentially) and pembrolizumab/ramucirumab, docetaxel/ramucirumab could be an option to consider as the next-line of treatment, though we need to acknowledge that we can’t directly apply the find...

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Mednet Member
Mednet MemberInvited Expert
Medical Oncology · Cedars-Sinai Medical Center
Answered on

Docetaxel and ramucirumab is an effective regimen for many patients and could be used as subsequent therapy. We lack data on the combination even after frontline immune checkpoint inhibitor therapy but for those who have good performance status, docetaxel and ramucirumab remains a good option for pa...

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