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What dose and fractionation would you recommend for a localized primary bone marginal zone lymphoma?

The patient has no bone marrow involvement.
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Duke University Medical Center
Answered on

This would be an unusual presentation for marginal zone lymphoma (MALT lymphoma) and not one I've actually encountered. In a large series from MSKCC, "soft tissue/bone" comprised 2% of cases treated with radiation therapy (IJROBP 2015;92:130). Case series from Princess Margaret (Cancer 2010;116:3815) and Brigham and Women's hospitals (Annals of Oncology 2007;18:672) reported osseous involvement in 0% and 1% of cases, respectively.

For most patients with localized MALT lymphoma, a dose of 24-30 Gy...

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