What dose constraints do you use for 15-25 fraction hypofractionated RT for cholangiocarcinoma?

For the GI tract, we use point dose constraints and 40cc “guidelines” that are based on our publications in LAPC and IHCC, where we analyzed bleeding events and found that is has been related to 40cc getting more than 50Gy in 25. So, we use 40cc over 45Gy in 25fx and 37.5Gy in 15fx. Bleeding is at a much higher risk in patients on anticoagulation or antiplatelet therapies. 2.6% vs 15% in the LAPC patients. The consequences have been relatively low with only transfusion and endoscopic laser resolving almost every case. There were no ICU stays and one surgery in the last 250-300 cases. Ulceration and perforation have not occurred. That seems to be a risk that was seen anecdotally or made up in the 2D era that is not happening in the 4D era, e...