What dose constraints do you use for 15-25 fraction hypofractionated RT for cholangiocarcinoma?
Higher radiation dose was shown to be associated with longer survival in Tao et al., JCO 2016. What dose constraints do you use when using these regimens?
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Radiation Oncology · Memorial Sloan-Kettering Cancer Center
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| 5Fx | 10fx | 15fx | 25fx | |
| Ablative dose | 50Gy | 60Gy | 67.5Gy | 75Gy |
| GI tract pt dose (0.2cc) | 30Gy | 40Gy | 45Gy | 60Gy |
| Bile Duct pt dose (0.2cc) | 40Gy | 65Gy | 70Gy | 80Gy |
| Liver – GTV Mean dose + 700cc below + 1/3 liver over | 15Gy | 20Gy | 24Gy | 28Gy |
| Mean dose CP... |
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Mednet MemberInvited Expert
Radiation Oncology · Memorial Sloan-Kettering Cancer Center
Answered on
For the GI tract, we use point dose constraints and 40cc “guidelines” that are based on our publications in LAPC and IHCC, where we analyzed bleeding events and found that is has been related to 40cc getting more than 50Gy in 25. So, we use 40cc over 45Gy in 25fx and 37.5Gy in 15fx. Bleeding is at a...
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