What dose constraints do you use for hypofractionated radiotherapy for breast cancer undergoing regional nodal irradiation?

I offer hypofractionated treatment with RNI for patients following lumpectomy or mastectomy without reconstruction off trial. In those patients, in terms of constraints, I have typically used the Alliance trial hypofractionated arm constraints.

Long Answer:

Currently, I offer hypofractioned RNI tx for patients only on clinical trials. The two trials that inform my treatment regimen/dose constraints are MA.39 and FABREC.

As you are aware, MA.39 is a randomized trial for lumpectomy and mastectomy patients with limited nodal burden. When enro...