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What dose do you use for postoperative rectum boost?

NCCN allows a range from 5.4-9 Gy for adjuvant boost and German trial used 55.8 Gy. What factors might sway you to give a higher / lower dose? Is more toxicity with higher dose seen?
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What total dose do you use including sequential or simultaneous boost after/with 45 Gy to the pelvis for post-operative rectal radiation therapy?

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4 Answers
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Radiation Oncology · University of North Carolina at Chapel Hill
Answered on

To the best of my knowledge there is no good information on this topic. I rarely use post RT nowadays. However, when I do, I have not gone higher than 54 Gy when it is truly an adjuvant treatment, and I often stopped at 50.4 Gy. The main limiting factor is toxicity, both small bowel and residual rec...

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Radiation Oncology · Sunnybrook Health Sciences Centre
Answered on

We use 50.4Gy and very rarely go to 54Gy.

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Radiation Oncology · Memorial Sloan-Kettering Cancer Center
Answered on

max point dose of 65Gy and <40 cc over 55Gy (guideline not limit).

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Radiation Oncology · Memorial Sloan-Kettering Cancer Center
Answered on

We use 54Gy as well, but limit the small bowel dose to max point dose of 55Gy and <40 cc over 45Gy (guideline not limit). Often IMRT is necessary due to fixed small bowel in the pelvis. It is important to be very cautious with apparently fixed small bowel in the pelvis.

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