What dose regimen would you use to treat a patient with locally advanced esophageal SCC of the mid-esophagus who refuses chemo and surgery, agreeing only to radiation alone?

Topics: Radiation Oncology • Gastrointestinal Cancers

Answer from: Radiation Oncologist at Community Practice

The 5Y survival of RTOG 8501’s RT alone arm was 0%. They used 64/32 Gy. So... I tend to think that RT alone is purely palliative and generally stick with 40/15 to provide palliation and hopefully some local control. 50/25 not unreasonable, but please don’t use the RT alone arm of the che...

Answer from: Radiation Oncologist at Academic Institution

I would stick with the standard 50.4Gy/28 fractions as established by the RTOG 8501 and Intergroup 0123 trials. Though there's an understandable impulse to give higher dose in this situation (and I myself have used an integrated boost to 56Gy/28 fractions in the past), there simply is no randomized ...

Comments

Radiation Oncologist at Mount Sinai Medical Center
I agree with Dr. @Abraham J. Wu that there is no c...

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