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What evaluation do you do in patients with hypertension and persistently elevated aldosterone/renin ratio (over 20) but without an elevated aldosterone level (under 10 ng/dL)?

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How do you approach hypertensive patients with persistently high aldo/renin ratio but normal aldosterone level?

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Endocrinology · Johns Hopkins Department Of Endocrinology Diabetes And Metabolism
Answered on

Patients with proven primary aldosteronism (based on pathology and postop aldosterone levels) can have plasma aldosterone levels <10 ng/dL. Repeating the levels, especially after optimizing their medications, can improve the test's sensitivity. The key in such cases is a PRA level <1 ng/dL. In the a...

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