What factors do you take into account when deciding the length of adjuvant temozolamide in GBM?
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What duration of adjuvant temozolomide do you offer for patients with GBM after GTR and temo/RT?
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1 Answer
Mednet MemberInvited Expert
Neurology · MD Anderson Cancer Center
Answered on
The field is evolving from 12 cycles to 6 for IDH-wildtype GBM in recent years, on the basis of some retrospective studies and notably the prospective Spanish study GEINO 14-01 - there does not seem to be much OS benefit, and there are also toxicity concerns (myelosuppression, hypermutation). Extens...
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