What factors do you take into account when deciding which gene expression assay to utilize when making adjuvant treatment decisions in patients with non-metastatic breast cancer?

What factors do you consider most important when selecting a gene expression assay for treatment decisions in non-metastatic breast cancer?

• Predictive value for chemotherapy benefit
• Predictive value for endocrine therapy benefit
• Prognostic value for recurrence risk
• Validation in both node-negative AND node-positive disease
• Validation in FFPE specimens
• Extent of insurance coverage
• Utility in resolving discordance between clinical and genomic risk
• Capability to confirm tumor subtype
• Accuracy in low ER/PR expression tumors
• No specific factors, I mainly use Oncotype due to familiarity
• No specific factors, I mainly use Mammaprint due to familiarity
• No specific factors, I mainly use other gene expression assays due to familiarity
• Other