What first line regimen for metastatic esophageal or GEJ adenocarcinoma would you use in an elderly patient (>80) with medical comorbidities?

I believe that there is no one right answer to this question. Elderly patients with chronic health problems require a full assessment before considering a particular treatment regimen. By "full", I mean learning as much about them as possible, including not just their performance status, renal funct...

Totally agree with Dr. @Dr. First Last's recommendation, may consider to add Nivolumab to the dose reduced CAPOX or FOLFOX if the PD-L1 CPS>=5 based on the Checkmate 649 study result.

This is always a tough question. At least in colon cancer, there is evidence that an elderly patient with co-morbidities would not benefit from the addition of oxaliplatin to fluorouracil infusion. However, the disease burden for lower tract cancers tends to be less than for upper tract disease. For...

For an elderly patient with medical comorbidities but still adequate performance status, I believe doublet chemotherapy with a regimen such as FOLFOX can still be considered. I may utilize an upfront 20% or even 40% dose reduction in which the recent GO2 phase 3 randomized trial appears to validate ...