What goes into your decision making when choosing between oral and intravenous bisphosphonate therapies for osteoporosis?
Do you consider the lower risk of MRONJ to motivate you to preferentially choose oral therapy? Does more severe bone disease at baseline move you towards IV?
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Which factor most influences your choice between oral and IV bisphosphonate therapy for osteoporosis?
12 physicians have voted
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2 Answers
Mednet MemberInvited Expert
Endocrinology · Boston University School of Medicine
Answered on
From my perspective if you are going to give a bisphosphonate IV is preferred since it is convenient and there is no risks of GI side effects and issues of compliance. I do not think there is any significant difference in causing ONJ and subtrochanteric femoral fractures. However my preference is De...
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Mednet Member
Rheumatology · Baptist Health Jacksonville Rheumatology
Answered on
If I have a patient with a long list of allergies, mast cell activation syndrome/disorder, or intolerances to multiple medications, I tend to favor oral bisphosphonates over the IV because of the need for multiple sedating pre-medications (benzo, steroids, histamine, etc) prior to the IV zoledronic ...
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