What is an appropriate dose for definitive radiation of a stage IE EBV+ polymorphic B-cell lymphoproliferative disorder?
The patient is a 75 yo immunocompetent man who has a history of inverted papilloma of the sinuses and presented with a new lesion in the right maxillary sinus. Pathology showed a polymorphic B-cell lymphoproliferative disorder, EBV+, with no concern for an EBV+ DLBCL. Pathology noted that the cells are monoclonal/plasmacellular proliferations seen in association with impaired immunity, in this case likely immune senescence.
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · UCSD Radiation Oncology
Answered on
This is a very unusual presentation for EBV associated polymorphic B-cell lymphoproliferative disorder as most cases are seen in the post-transplant or other immune-compromised patients. In immuno-competent patients, this condition is felt to be related to immune senescence.
The range of clinical be...
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