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What is the appropriate dose to the dissected node-negative neck with indication for radiation due to advanced primary?

Is it 54 Gy or do we worry about hypoxia and need to go to 60 Gy? Does it change based on site (i.e., oral cavity versus a T4N0 larynx)? There appears to be a range between 50-60 Gy based on previous discussions, examples below: https://www.themednet.org/question/1465 https://www.themednet.org/question/882 https://www.themednet.org/question/9454 https://www.themednet.org/question/12384
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What is your dose of choice for DISSECTED negative neck?

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2 Answers
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Radiation Oncology · University of Florida
Answered on

60 Gy/30 fractions if HPV negative.

50 Gy/25 fractions or equivalent if HPV-positive OPX.

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Radiation Oncology · University of Texas MD Anderson Cancer Center
Answered on

The doses vary dependent on fractionation.

In the SIB-IMRT era of 30 fxs, our (MDA) standard dosing has been 60 Gy to the tumor bed, 57 to the operated bed, and 54 to the non-operated bed; if we were sequencing at 2 Gy, it would be 60, 56, and 50.

The question as I interpret it based on the above is s...

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