What is the appropriate target volume for a transformed glioma in a contralateral brain lobe to a previous low grade glioma treated with resection alone?

First, I would determine if there is no imaging evidence of progression at the previously resected site of the glioma. If so, I would not irradiate it now but use the volume as an avoidance structure in the planning of the current contralateral high-grade glioma. The rationale: we do not know when t...

I would favor treating only the transformed glioma site in the contralateral brain lobe, especially if the previously resected low-grade glioma was IDH mutant, because the patient's highest risk for mortality comes from the higher-grade tumor. I would treat the high-grade (transformed) site with 59....