What is the best adjuvant treatment for resected NSCLC?

This is going to be a several part answer to a seemingly straightforward question. I’ll break this down into a few parts: 1) Which chemotherapy, 2) Targeted therapies in molecular subsets, 3) Anti-angiogenic agents, 4) The role of PORT (post-operative radiation therapy).

1. Which Chemotherapy: The simple answer, which is based on the greatest amount of data, is Cisplatin/Vinorelbine for patients with Stage IIb or greater disease (Best reference: Pignon et al, JCO 2008; LACE: large meta-analysis of 5 largest adjuvant trials, IALT, ALCPI, ANITA, JBR-10, Big Lung Trial). Only Stage II or greater had a benefit, overall absolute 5% survival benefit compared with observation. Data from the CALGB 9633 study showed some benefit with Carbo/Taxol in ...