What is the best approach to manage iron overload secondary to both heterozygous HFE gene mutation and two heterozygous aceruloplasminemia gene mutations?

Topics: Hematology • Benign Hematology • Iron Homeostasis

Any particular labs or imaging indicated?

Answer from: Medical Oncologist at Academic Institution

The question is good as both heterozygotes for HFE and double heterozygotes (I suspect the same applies for aceruloplasminemia) for HFE are usually invisible. That being said, not always. What I do, if the increased iron is not urgent (normal LFTs, ferritins <1,500), is get them to become blood d...

Comments

at Vanderbilt University Medical Center
Dr. @Auerbach, thank you for that. Could you defin...

Medical Oncologist at Georgetown University School of Medicine
I think a target ferritin of 50 is reasonable (see...

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