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Hematologic Malignancies • Medical Oncology • Lymphoma • NCI-CCC Tumor Board Question • NCI-CCC Lymphoma Tumor Board Question • DLBCL • City of Hope
What is the best treatment approach to a patient with HGBCL with FISH translocation of BCL-6 and c-Myc given new classification of this entity?
Answer from: Medical Oncologist at Academic Institution
The International Consensus Classification (ICC) and the 2022 WHO 5th Edition have sought to refine the approach to high-grade B-cell lymphomas (HGBL) with c-Myc and BCL-6 rearrangements. As the questionnaire astutely implies, the WHO now excludes cases with concurrent c-Myc and BCL-6 rearrangements...
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Answer from: Medical Oncologist at Community Practice
I usually use dose-adjusted R-EPOCH in fit patients with normal EF.