What is the best way to approach elevated liver enzymes in patients treated with combination TKI and immunotherapy?

Topics: Genitourinary Cancers • Medical Oncology • Pharmacology

Are there any clinical features that can inform etiology/which medication to hold?

Answer from: Medical Oncologist at Academic Institution

We rely on clinical judgment in this case as both TKIs and immunotherapies can cause elevation of liver enzymes. Currently, the recommendations in case the attribution of the hepatitis is questionable is to hold both drugs and to check the liver enzymes daily; if it improves, then it is likely due t...

Comments

Medical Oncologist at University of South Dakota School of Medicine
Appreciate the reference.

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