Unfortunately, many of the large trials have not identified a strategy that is effective for CIPN. It is important to tell patients to avoid some supplements. Studies have shown that acetyl-l-carnitine can make the symptoms worse. There is some evidence that exercise may result in decreased symptoms...

There are not many studies looking at treatment for CIPN.  Usually our med onc start the patients on Vitamin B6 and if that is not effective Gabapentin.  I also recommend acupuncture for patients which seems to be effective especially in patients not responding to Gabapentin.  However...

The best way to approach it is with prevention and we found cryotherapy to be very effective and inexpensive method of prevention. Unfortunately, it is not applicable for oxaliplatin.